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Fatal Familial Insomnia, Graft Versus Host Disease, and Other Unusual Diseases

You’ve probably seen at least one Dateline featuring crazy diseases, strange medical conditions with even stranger names. The poor souls who are diagnosed with these syndromes make us thankful that they are indeed rare. There are probably hundreds of these, but here is my list of the top five most unusual.

1. Alice in Wonderland Syndrome: Named after the distortion that Alice experienced during her trip down the rabbit hole, this syndrome occurs mainly in children. To those with this syndrome, body image and visual perception are altered, mainly the size and parts of objects. For instance, someone’s head may appear larger than it actually is or the ground may appear too close. In some cases, people report distortion in time, touch and sound. The syndrome is thought to be a side effect of another condition, such as migraines, Temporal Lobe Epilepsy, or the Epstein-Barr virus. Because of this, Alice in Wonderland Syndrome is treated by treating these underlying causes.

2. Ondine’s Curse: Also called Congenital Central Hypoventilation Syndrome (CCHS), this condition was named after a mythical water nymph named Ondine, who put a curse on her mortal lover. He swore to her that he would love her with his every waking breath, and upon catching him in an unfaithful act with another woman, she cursed that he would forget to breathe if he fell asleep. This did eventually happen, and her lover died. This rare condition is actually a form of sleep apnea, when a person suffers from respiratory arrest during sleep. In extremely rare cases, this apnea also occurs while the person is awake.

3. Fatal Familial Insomnia: This rare inherited disease affects the thalamus, the area of the brain responsible for sleep. People with this disease physically can’t fall asleep, so their body deteriorates and they eventually die. What begins as progressive insomnia ends 18 months later with hallucinations, incontinence, Dementia, and death. It usually occurs in middle age, and is currently untreatable. It has only been found in 100 people and, since it’s hereditary, in just 40 families.

4. Seasonal Affective Disorder: I’m sure you’ve felt it: the blah caused when the gloom and gray of the winter months drags on too long. However, Seasonal Affective Disorder is more serious than just the winter blues. Otherwise known as SAD, this type of depression is also related to the seasons. People with this mood disorder have normal mental health the majority of the year, but become depressed–sometimes sleeping too much or having less energy–during the winter months. Symptoms also include overeating, weight gain, and morning sickness, as well as the classic symptoms of depression, including withdrawal, pessimism, and lack of pleasure in things that used to make one happy. Although it is not certain what causes SAD, some believe it to be due to light, or rather lack of. Because of this, treatment includes light therapy with sunlight or bright lights, as well as a supplement of melatonin. SAD can also be seen in the spring and summer months, although it is less common.

5. Graft Versus Host Disease: This disease is the opposite of what may happen after a transplant, when the body attacks the transplanted organ. Instead, this disease happens after a bone-marrow transplant when the transplanted cells attack the host organs and tissue. when the transplanted organ attacks the host. Only twins have identical bone marrow tissue, so a donor is only a close match. This slight difference is enough to cause the T cells (white blood cells) to see the host body tissues as foreign. The new bone marrow then attacks the body. The risk of GVHD can be lessened by taking drugs that suppress the immune system.

Enchanted Coloring Pages, Online Games and Activity Ideas

Enchanted is a fun new movie that has captured the hearts of many little girls. The movie features a new “Disney Princess” named Giselle who is looking for her true love. With a funny chipmunk named Pip, an evil Queen, and a host of other fun characters this movie is sure to entertain. Have an Enchanted fan? Then have a special day for them filled with Enchanted activities. Here you will find where to get free printable coloring pages, free online games, and activity ideas.

Free Printable Coloring Pages

At the following link you will find three character coloring pages and twelve pages of scenes from the movie.

http://www.coloring-book.info/coloring/coloring_page.php?id=153

Free Online Games

Enchanted Crossing

http://www.girl.com.au/php/games/enchanted/

In this game you have to help the characters of the Disney movie Enchanted cross Time Square. You use your arrow keys to make them move.

Jumping Pip

http://www2.disney.co.uk/DisneyMovies/enchanted/

In this game you use the number keys one through six to help Pip jump higher, do tricks and eat goodies, but don’t let him eat the poisoned apple or you’ll lose points.

The following games are all found at this link:

http://adisney.go.com/disneyvideos/liveaction/enchanted/

Nab The Apples

In this game you use the arrow keys (the up arrow makes you jump) to gather apples and points. But watch out for the poisonous apples.

Character Match

In this game you match cards that show pairs from Disney movies, like Ariel and Prince Eric, Sleeping Beauty and the Prince, and Jasmine and Aladdin.

Activity Ideas

Don’t want to print out pages and get out the crayons? Let your Enchanted fan color online. This link will take you to a page where you can color pages by point and click.

http://www.thedollpalace.com/coloring-pages/sec30-Disney/pic3931-enchanted.html

Sing-A-Long

http://adisney.go.com/disneyvideos/liveaction/enchanted/

Choose a song, then watch the screen and sing along with the characters from the movie.

Make a Face

Provide your child with a paper plate, and fun food items such as apple slices, carrots, raisins, chocolate chips, marshmallows and anything else you think might be fun. Let them play with their food and make faces on the plate from the items, just like Giselle makes her “Prince” from items she find in the cottage.

Make a Tiara

Where would a princess be without her tiara? Cut out a tiara shape from thick cardstock and then provide your child with glitter, glue, markers, and pretty stickers to decorate it.

Princess Dress-Up

http://www.thedollpalace.com/dollmaker/cartoon/princess/dress-up.php

Let your princes dress up a princess doll in all sorts of fun dresses, hairstyles, gloves, hats, earrings, hair accessories, crowns, and necklaces. Then create a fun background, and create a pet for your princess.

E-Commerce Based Wholesale Business

E-business, or E-commerce, is certainly a big revolution which has changed the face of world business. It plays a vital role in simplifying the business processes globally and even with businesses conducted on the domestic scene.

Almost all major types of goods can be purchased online with the implementation of e-commerce. If you are planning on buying the wholesale goods from the international markets, it is much more convenient to run your operations online, providing that you find the right wholesaler. It is a lot more affordable than operating offline and traveling overseas, and it is a safer to a larger extent.

E-commerce has made the world business a lot easier and the world seems much smaller than in the past. Along with the advantages, there are few drawbacks which can be overcome with the right resources. The distance could also mean that you will be unable to understand the legal requirements of the wholesaler’s country.

The best resources to handle such situations are by taking legal help, especially from the wholesaler’s country. There are plenty of law firms with the wholesale expertise. You could look up the Internet for such companies and contact them in order to see how best they can help you to safeguard your interests and your investments.

This article endevors to inform about obtaining legal help with respect to the e-commerce based wholesale market.

You can always find a list of the legal help companies on the yellow pages. They will be listed along with their names, addresses and telephone numbers. The best part is you can even check on the credibility and efficiency of the law firms on such directories. All you’ll need to do is check out the reviews about the firms and you’ll be able to find the right legal help for your wholesale business.

There are many service companies and websites which operate round the clock to provide legal help concerning the wholesale market. You could even find the websites and companies run by the government.

The most common legal issues which are critical to be managed in the wholesaler’s country are as follows: Paperwork and documentation required in the wholesalers country, payments to the concerned authorities, verification of the wholesalers credibility, liability and damages while transporting the goods ,insurance procedures, privacy policies and the nondisclosure agreements, and international money transfers.

There are many reputed wholesaler companies which will take care of all the legal works for you. They might be priced a little on the higher side but you will surely have peace of mind when you are operating with such wholesalers.

There are few things which you could do on your end as well if you want to get more information about the legalities concerning the wholesale market in that country. There are plenty of online forums which are dedicated to wholesale related issues. You can register on such websites for free and have your concerns addressed by the experienced buyers. You could also check with them about the local legal help from the wholesaler’s location as well. Doing some groundwork from your end will help you understand the e-commerce scenario a lot better.

Diagnosing Cystic Fibrosis In Children

Cystic Fibrosis is an inherited condition in which a defective gene disrupts the normal production of mucus, causing it to become thick and sticky. As the mucus cannot move properly, it begins to build up in the body and form obstructions in areas such as the lungs and pancreas. The result is often severe lung damage, digestive problems and malnutrition.
Cystic fibrosis is found in over 70,000 children and adults worldwide, with an additional 1,000 new cases being diagnosed each year in the United States alone. More than 70% of cystic fibrosis patients are diagnosed by age two, as there are several common signs and symptoms that are often displayed early in childhood.

Common Signs and Symptoms of Cystic Fibrosis: Salty Sweat

One of the most common signs first noticed by parents is a strong taste of salt when kissing their child. This is due to the fact the defective gene involved with cystic fibrosis changes the way sodium chloride (salt) is moved in and out of cells. As a result, the body loses higher than normal amounts of salt as it sweats.

If a child becomes overly warm and produces a lot of sweat, parents may notice signs of salt loss, such as dehydration, weakness, or tiredness.

Common Signs and Symptoms of Cystic Fibrosis: Breathing Difficulties

The genetic mutation in cystic fibrosis causes the normally thin and watery mucus in the body to become thick and sticky. As it builds up in the respiratory airways, breathing becomes more difficult. Parents may observe their child wheezing, acting short of breath, or coughing a lot. Thick sputum is sometimes brought up while coughing, though parents may not notice this in young children who have a tendency to swallow instead of spitting it out.

Common Signs and Symptoms of Cystic Fibrosis: Frequent Respiratory Infections

People with cystic fibrosis are prone to frequent respiratory infections, as their blocked airways are prime breeding ground for bacteria. These respiratory infections take the form of sinus infections, bronchitis, pneumonia, or lung infections caused by unusual strains of bacteria.

Frequent respiratory infections may be the sign that draws the attention of a doctor when other symptoms of cystic fibrosis are not extremely obvious or present.

Common Signs and Symptoms of Cystic Fibrosis: Digestive and Bowel Problems

The thick, sticky mucus found in cystic fibrosis commonly blocks the ducts of the pancreas. This results in the digestive enzymes produced by the pancreas not reaching the small intestines, where they are needed to break down food. People with cystic fibrosis commonly have bulky, greasy, and foul-smelling stools because of this. They may also experience on-going diarrhea, constipation, painful gas, or intestinal blockages.

An intestinal blockage is the earliest sign of cystic fibrosis in babies. Fifteen-20% of newborns with cystic fibrosis have meconium ileus, which is an obstruction of the intestines due to the meconium being overly thick. Meconium is the dark sticky stuff (made up of amniotic fluid, mucus, and bile) that is found in the intestine at birth and passed out of the system in the baby’s first bowel movement. The body uses the pancreatic digestive enzymes to break down meconium, but these may not be readily available in babies with cystic fibrosis.

Common Signs and Symptoms of Cystic Fibrosis: Poor Growth and Weight Gain

Without the help of the pancreatic enzymes, the body cannot absorb proteins and fats properly. Children with cystic fibrosis often become malnourished because they cannot pull the required nutrients out of their food. Babies may have ravenous appetites, yet not put on weight or show proper growth during the first few weeks of their life. Older children frequently fall below the height and weight expectations for their age. They may also show signs of poor bone development and low bone density.

A Note on the Signs and Symptoms of Cystic Fibrosis

There are more than 1,400 possible ways for the gene involved with cystic fibrosis to mutate, with each mutation causing a slightly different set of symptoms to be displayed. This means one child may have several symptoms, while another will experience only one or two. Signs of cystic fibrosis may show right away in one child, while another will appear to be fine for a while. The severity of symptoms may change over time and with age, as well.

Missouri Residents – Beware of “Pure Comparative” Law

If you are a resident of Missouri, and have only liability auto insurance, there is something your insurance agent is not telling you.
Now, of course you understand that is you have only liability coverage, damages in an accident are paid to the other party involved only if you are at fault. Your damages, in that situation, are your own responsibility. Liability insurance is only available to a customer is there is no lien on their vehicle. Many consumers choose this coverage because it is the minimum required by law, and many justify having only liability because of the cost difference in comparison to full coverage, especially if their car is older or not assessed at a high value.

However, as a Missouri resident who fell into this category and who has recently been in a car accident, I would like to shed some light on this situation and provide some information that is not well known.

In Missouri, there is a law pertaining to auto accidents that is called, “Pure Comparison.” Missouri is not the only state that has this law. What it means is that the insurance company has the right to assess some fault to the party who was not in fault of the accident. We’ll use my own accident as an example. I was driving westbound on a major highway. This is a divided highway – two lanes westbound, two east. A median seperates the lanes, and a yield sign is in the median. I was driving within the speed limit. It was dark, and my lights were on. A van went through a median (and the yield sign in the median) to go northbound on a cross street. I did what anyone would do; I braked and swerved to attempt to avoid hitting the van.

The party at fault got a ticket for failure to yield; I did not receive a ticket.

However, the other party’s insurance company is attempting to assign to me some percentage of fault – which apparently, in Missouri, is legal and common place. Since I only had liability insurance at the time, my insurance company has no real interest in arguing my case to the opposing company. I’m pretty much on my own.

So, the lesson to be learned is this; if you are a Missouri resident, with only liability insurance, and you have an accident in which you are not at fault, you will be punished for not carrying full coverage insurance. Have full coverage, or have a large savings account to compensate for your losses. If you are not a Missouri resident, spend some time researching insurance laws in your own state. You never know when you’ll have to know these things.

Best House cleaning tools of 2019

Every home should have sure cleanup tools; untiring tools which will facilitate the cleaner, get the job done quickly and with efficiency. There is little doubt that if you don’t have home cleanup tools or if you don’t keep your home clean, it’ll expose the inmates to health hazards and should discourage few friends, colleagues and associates from visiting. The beauty of getting these must-have home cleanup tools is that they’re going to change you to manage, organize, and keep on track with daily, weekly, monthly and annual cleanup assignments.

Let’s study a few of them:

Auto spin hand push mop is easy to clean the dust on the floor especially from crevices. 3-in-1 broom, dustpan, and garbage bin. Comes with an automatic pan inside for storing dust. Doesn’t require power and is energy saving. Feather microfiber dusters is another one which efficiently cleans all dust from windows, table-tops, and wardrobes, bookshelves. Microfibers are super absorbent and absorb more in presence of water. Get the ones with long handles that will help you reach higher surfaces.Vacuum cleaners are essential for proper dust and dirt removal from your office or home. They can also be used in cars. They come with or without bags or cords. aspirapolvere dyson v8 is one of the best vacuum cleaners out there.

Squeegees and wipers another very important tool for use on a daily basis. Useful in cleaning bathrooms and hard floors. Can be used in pushing water from floors. Spray bottle is one of the things you really need to keep around your home always. So that, if you have got to rinse something in your home, you’ll be able to use spray bottle with success anytime, any day with no stress. Scrubs and Sponge Mops generally used in washing utensils, cleaning glass walls, windows, and table tops. They scrub the dirt from the utensil and remove dust efficiently. You generally need to clean the sponge after a couple of uses. Cleaning gloves are useful to protect your hands from dust and water while cleaning. It protects your skin from chemicals and cuts.

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